Acetyl heptapeptide-4 | CAS 1459206-66-6 | Anti-Allergic Peptide for Skin Barrier and Sensitivity

Description Contents hide 1 Product Description 2 Product Specifications 3 Mechanism of Action 3.1 1. Inhibition of Neurogenic Inflammation 3.2 2. Suppression of Pro-Inflammatory Cytokines 3.3 3. Mast Cell Stabilization 3.4 4. Enhancement of Skin Barrier Function 3.5 5. Immune Balance and Homeostasis 3.6 6. Cellular Antioxidant Defense 3.7 7. Synergistic Use with Barrier-Repair Actives 4 Side Effects 5 Keywords 6 Shipping Guarantee 7 Trade Assurance 8 Payment Support 9 Disclaimer Product DescriptionAcetyl heptapeptide-4 is a synthetic bioactive peptide developed for advanced cosmetic and dermatological research focusing on sensitive skin, allergy-prone skin, and barrier dysfunction. This seven-amino-acid sequence is acetylated to enhance its molecular stability and improve transdermal penetration. It has demonstrated strong anti-allergic and anti-inflammatory activity in in vitro studies, making it a valuable ingredient in modern cosmetic peptide research.The peptide primarily functions as a neuromodulatory and immunomodulatory signaling molecule, influencing the communication between epidermal keratinocytes, dermal fibroblasts, and immune cells such as mast cells and Langerhans cells. By regulating these interactions, Acetyl heptapeptide-4 helps minimize the excessive inflammatory reactions that often cause skin redness, irritation, and hypersensitivity.From a biochemical perspective, Acetyl heptapeptide-4 works by downregulating key mediators of neurogenic inflammation, including Substance P (SP), Calcitonin Gene-Related Peptide (CGRP), and Prostaglandin E2 (PGE2). It further inhibits the overproduction of pro-inflammatory cytokines such as IL-1α, IL-6, and TNF-α while enhancing the synthesis of epidermal lipids and tight junction proteins critical for maintaining barrier integrity.Research has shown that topical formulations containing Acetyl heptapeptide-4 can help restore normal barrier function and reduce the stinging or itching sensations associated with environmental stress or product overuse. These properties make it particularly relevant for sensitive-skin models, post-procedure recovery formulations, and barrier-repair cosmetic studies.Acetyl heptapeptide-4’s acetyl modification enhances its lipophilicity, allowing better skin penetration and prolonged bioavailability compared to non-acetylated analogs. The heptapeptide sequence itself is engineered to mimic natural skin defense peptides, thus supporting the skin’s innate immune balance. Through this dual mechanism — strengthening the barrier and modulating inflammatory response — Acetyl heptapeptide-4 stands out as an innovative tool in cosmetic peptide research.Researchers have also explored its role in reducing allergic-type responses triggered by irritants and allergens. In controlled cell culture experiments, Acetyl heptapeptide-4 was shown to inhibit mast cell degranulation and histamine release, indicating its capacity to minimize redness and discomfort associated with allergic reactions. Moreover, its low cytotoxicity profile makes it a safe and reliable candidate for topical peptide formulation studies.With the rising prevalence of sensitive skin conditions due to pollution, lifestyle stress, and cosmetic overexposure, Acetyl heptapeptide-4 provides a scientifically validated solution for soothing irritation and restoring barrier function. As part of ongoing cosmetic peptide innovation, it continues to serve as an essential molecule in research dedicated to skin homeostasis, inflammation control, and dermal resilience.Product SpecificationsPropertySpecificationProduct NameAcetyl heptapeptide-4CAS Number1459206-66-6SynonymsN-Acetyl-Heptapeptide-4Molecular FormulaC₃₅H₅₇N₁₁O₉Molecular Weight771.91 g/molPurity≥99%AppearanceWhite to off-white lyophilized powderSolubilitySoluble in water and aqueous buffersStorage Temperature2–8 °CCategoryCosmetic peptideApplicationsAnti-allergic research, skin barrier recovery, redness reduction, skin-calming and sensitivity studiesFormulationSuitable for topical serum, cream, or emulsion research formulationsStabilityStable under recommended storage conditions for ≥24 monthsAnalytical VerificationHPLC, MS, and NMR confirmedSupplier TypeFactory peptide supplierIntended UseFor laboratory research use onlyBatch AnalysisEach batch supplied with a Certificate of Analysis (CoA)Handling NotesAvoid exposure to high temperature, UV light, and moisture; reconstitute using sterile water under aseptic conditionsMechanism of ActionAcetyl heptapeptide-4 exerts its biological effects through a multifactorial mechanism involving both immune and neural pathways. Its activity in modulating inflammatory responses and promoting skin homeostasis has been well characterized in cosmetic and dermatological research.1. Inhibition of Neurogenic InflammationThe peptide modulates the release of neuropeptides such as Substance P and CGRP from sensory nerve endings. These neuropeptides are key mediators of neurogenic inflammation, which is responsible for sensations of stinging, redness, and discomfort in sensitive skin. By suppressing these mediators, Acetyl heptapeptide-4 helps restore normal skin sensitivity thresholds and reduces inflammation-related erythema.2. Suppression of Pro-Inflammatory CytokinesThrough cellular signaling pathways involving NF-κB and AP-1, Acetyl heptapeptide-4 inhibits the production of inflammatory cytokines like IL-1α, IL-6, and TNF-α. This action prevents the amplification of inflammatory cascades that contribute to skin irritation and allergic responses. The result is a visible reduction in redness and swelling, as demonstrated in laboratory keratinocyte and fibroblast co-culture models.3. Mast Cell StabilizationAcetyl heptapeptide-4 helps prevent mast cell degranulation, a process that releases histamine and other inflammatory mediators responsible for itching and allergic reactions. Stabilizing mast cells is critical in maintaining skin comfort and preventing overreaction to environmental stimuli, fragrances, or harsh surfactants.4. Enhancement of Skin Barrier FunctionThe peptide increases the expression of key structural proteins such as filaggrin, involucrin, and occludin, which are integral components of the epidermal barrier. It also promotes the synthesis of ceramides and fatty acids, essential for maintaining hydration and reducing trans-epidermal water loss (TEWL). This leads to more resilient skin capable of defending itself against irritants and allergens.5. Immune Balance and HomeostasisBy modulating the crosstalk between keratinocytes and immune cells, Acetyl heptapeptide-4 promotes a balanced immune response. It encourages the release of anti-inflammatory cytokines like IL-10, reducing hypersensitivity reactions while preserving the skin’s natural defense capabilities.6. Cellular Antioxidant DefenseThe peptide indirectly enhances the skin’s antioxidant response by upregulating genes associated with detoxification and reactive oxygen species (ROS) neutralization. These effects contribute to the prevention of oxidative stress-induced inflammation, further protecting sensitive skin.7. Synergistic Use with Barrier-Repair ActivesIn research formulations, Acetyl heptapeptide-4 has been shown to complement ingredients such as panthenol, niacinamide, and ceramides. This synergy promotes accelerated recovery in barrier-compromised skin and enhances comfort in individuals prone to sensitivity or redness.Side EffectsAcetyl heptapeptide-4 has demonstrated excellent biocompatibility and safety in vitro and in reconstructed human epidermal models. No cytotoxicity, irritation, or sensitization was observed within typical experimental concentration ranges.The peptide should, however, be handled under controlled laboratory conditions to maintain stability and prevent contamination. It is recommended to perform patch compatibility and concentration-dependent cytotoxicity studies when developing new formulations.Overexposure to light or elevated temperatures may reduce its stability; therefore, proper storage (2–8 °C) is crucial. The peptide is strictly intended for laboratory research use and not for direct application to human subjects or therapeutic use.KeywordsAcetyl heptapeptide-4, anti-allergic peptide, skin barrier peptide, soothing peptide, cosmetic peptide, sensitive skin research, peptide supplier China, OEM peptide production, high-purity cosmetic peptides, bulk peptide manufacturerShipping GuaranteeAll shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.Trade AssuranceWe ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.Payment SupportWe provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.https://arizona-mall.com/wp-content/uploads/2025/11/Acetyl-Heptapeptide-4-Hexapeptide-8-Pentapeptide-4-CAS-1253115-74-0-Acetyl-Heptapeptide-4-Hexapeptide-8-and-CAS-1253115-74-0.mp4DisclaimerAll products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.