Acetyl Hexapeptide-49 | CAS 1969409-70-8 | Anti-Allergen and Skin Soothing Peptide

Description Contents hide 1 Product Description 1.1 Molecular and Functional Insights 2 Product Specifications 3 Mechanism of Action 3.1 1. Sensory Nerve Signal Regulation 3.2 2. Cytokine and Chemokine Downregulation 3.3 3. Barrier Reinforcement and Lipid Metabolism 3.4 4. Neuro-Immune Balance Restoration 3.5 5. Cellular Viability and Stress Resistance 3.6 6. Compatibility and Synergistic Action 4 Side Effects 5 Keywords 6 Shipping Guarantee 7 Trade Assurance 8 Payment Support 9 Disclaimer Product DescriptionAcetyl hexapeptide-49 is a synthetic hexapeptide designed to improve skin resilience and comfort by modulating neuro-sensory responses and barrier homeostasis. Known as an effective anti-irritation and skin-calming agent, it acts at the molecular level to reduce hypersensitivity reactions, making it valuable in dermatological and cosmetic peptide research aimed at sensitive or reactive skin.This peptide was originally developed to alleviate stimulation in mammalian skin cells while maintaining cell vitality and structural cohesion. Studies indicate that Acetyl hexapeptide-49 influences the expression of genes related to inflammatory modulation and sensory nerve activity. By decreasing the production of neuropeptides such as substance P and CGRP (Calcitonin Gene-Related Peptide), it helps mitigate redness, itching, and discomfort associated with external irritants.From a biochemical perspective, the acetylation of the peptide sequence enhances its lipophilicity, allowing better dermal penetration and interaction with sensory receptors in the skin. This modification increases stability during formulation and improves its performance in topical applications. Moreover, Acetyl hexapeptide-49 promotes keratinocyte differentiation and lipid synthesis, two key processes involved in maintaining a healthy epidermal barrier.Laboratory investigations have shown that this peptide can protect skin cells exposed to chemical irritants, UV radiation, or mechanical stress, effectively reducing inflammatory signaling and oxidative imbalance. By enhancing cell viability and supporting the synthesis of ceramides and structural proteins, Acetyl hexapeptide-49 contributes to a more balanced and tolerant epidermis.In cosmetic research, Acetyl hexapeptide-49 is often studied as an ingredient for soothing and repairing formulations targeting sensitive, reactive, or redness-prone skin. It demonstrates compatibility with a broad range of active peptides, humectants, and lipid-restoring compounds, allowing synergistic effects in complex formulations. Furthermore, its ability to regulate sensory responses makes it particularly useful in research related to neurocosmetic peptide development.Molecular and Functional InsightsAcetyl hexapeptide-49 operates through the modulation of the skin’s neuro-immuno-cutaneous system (NICS), which governs how nerve endings and immune cells respond to external stress. By rebalancing this interaction, the peptide can prevent exaggerated sensory reactions, often the root cause of irritation and chronic sensitivity. This biological approach differentiates it from traditional anti-inflammatory compounds, providing a more targeted pathway for soothing skin research.In vitro and ex vivo tests have revealed improvements in transepidermal water loss (TEWL), skin hydration, and recovery time after chemical stress exposure. Researchers have also noted enhanced tolerance to surfactants and other irritant compounds when pre-treated with Acetyl hexapeptide-49, indicating its protective and conditioning benefits.Overall, this peptide represents a new generation of neuro-soothing cosmetic actives, bridging molecular dermatology and skin barrier science. Its multi-targeted mechanism aligns with the growing demand for gentle yet effective bioactives that restore balance to sensitive and reactive skin conditions.Product SpecificationsItemDetailsProduct NameAcetyl Hexapeptide-49CAS Number1969409-70-8SynonymsExample 13; N-Acetyl-Hexapeptide-49Molecular FormulaC₃₄H₆₁N₉O₈Molecular Weight723.91 g/molPurity≥99%AppearanceWhite to off-white lyophilized powderSolubilitySoluble in water and ethanolStorage Temperature2–8 °CCategoryCosmetic peptideApplicationsSensitive skin research, anti-allergen peptide studies, barrier recovery, anti-irritation, and soothing formulationsFormulationSuitable for serum, cream, lotion, or gel-based cosmetic research formulationsStabilityStable under recommended storage conditionsShelf Life24 monthsSupplier TypeFactory peptide supplierIntended UseFor laboratory research use onlyMechanism of ActionAcetyl hexapeptide-49 exerts its biological activity primarily through neurosensory regulation and inflammation modulation, making it distinct from standard anti-inflammatory compounds.1. Sensory Nerve Signal RegulationIt interacts with neuronal receptors to reduce the release of neuropeptides involved in irritation, including substance P and CGRP. This action helps attenuate the perception of burning, stinging, and itching sensations while supporting a more balanced nerve–skin communication network.2. Cytokine and Chemokine DownregulationThe peptide reduces pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, preventing the cascade of irritation and redness typically associated with contact sensitivity. This process leads to a more resilient, less reactive skin profile.3. Barrier Reinforcement and Lipid MetabolismAcetyl hexapeptide-49 enhances the synthesis of key lipids and structural proteins, including ceramides, filaggrin, and involucrin. These molecules are crucial for maintaining an intact stratum corneum, reducing transepidermal water loss (TEWL), and improving hydration levels.4. Neuro-Immune Balance RestorationThis peptide modulates cross-talk between nerve endings and immune cells in the epidermis, promoting equilibrium within the neuro-immuno-cutaneous system. It ensures the immune response remains protective without triggering excessive inflammation.5. Cellular Viability and Stress ResistanceIn vitro experiments demonstrate improved keratinocyte survival and mitochondrial stability when cells are pre-treated with Acetyl hexapeptide-49. The peptide mitigates oxidative stress and maintains cellular vitality, ensuring optimal skin function even under environmental aggressors.6. Compatibility and Synergistic ActionAcetyl hexapeptide-49 shows high compatibility with calming agents like panthenol, bisabolol, and palmitoyl tripeptides, amplifying the overall soothing and reparative potential of cosmetic research formulations. This versatility makes it a valuable component in multi-functional skincare research.Side EffectsAcetyl hexapeptide-49 demonstrates a highly favorable safety profile in laboratory conditions. Cytotoxicity tests confirm that the peptide maintains cell viability even at high research concentrations. No signs of irritation, sensitization, or phototoxicity have been observed in reconstructed human epidermis models.However, as with all research peptides, optimal results depend on concentration and formulation stability. Overexposure to high temperature, oxidation, or UV light should be avoided to preserve bioactivity. Researchers are advised to perform standard in vitro safety assessments to verify compatibility before incorporating it into advanced cosmetic studies.This peptide is considered safe for experimental use but not for direct human or veterinary application.KeywordsAcetyl hexapeptide-49, anti-allergen peptide, skin-soothing peptide, sensitive skin research, anti-inflammatory cosmetic peptide, cosmetic peptide manufacturer, high-purity peptide supplier, OEM cosmetic peptide, China peptide manufacturerShipping GuaranteeAll Acetyl Hexapeptide-49 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.Trade AssuranceWe Acetyl Hexapeptide-49 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.Payment SupportWe Acetyl Hexapeptide-49 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.https://arizona-mall.com/wp-content/uploads/2025/11/Cosmetic-Raw-Materials-Peptide-Acetyl-Hexapeptide-49-CAS-1459205-54-9-Cosmetic-Raw-Materials-Peptide-and-Acetyl-Hexapeptide-49.mp4DisclaimerAll Acetyl Hexapeptide-49 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.