Acetyl hexapeptide-38 | CAS 1400634-44-7 | Collagen Stimulating Peptide for Skin Firming and Tissue Repair

Description Contents hide 1 Product Description 2 Product Specifications 3 Mechanism of Action 4 Side Effects 5 Keywords 6 Shipping Guarantee 7 Trade Assurance 8 Payment Support 9 Disclaimer Product DescriptionAcetyl hexapeptide-38 is a biomimetic, research-grade peptide engineered to modulate fibroblast activity within the dermal matrix. Known for its potent collagen-stimulating and adiponectin-enhancing effects, this compound has become a leading ingredient in anti-aging and tissue repair studies. Through its direct influence on dermal fibroblasts, Acetyl hexapeptide-38 promotes the thickening of the dermal layer and enhances subcutaneous volume, improving overall skin texture and firmness.In cosmetic peptide research, Acetyl hexapeptide-38 has been recognized for its unique dual action on both extracellular matrix (ECM) synthesis and adipocyte metabolism. It increases collagen type I and III production, supporting a stronger, more elastic dermal structure while concurrently encouraging localized lipid storage to restore youthful facial contours. These combined actions contribute to visible improvements in facial fullness, firmness, and elasticity observed in in-vitro and ex-vivo models.As a synthetic hexapeptide derivative, Acetyl hexapeptide-38 functions as a tissue repair promoter. It activates fibroblasts and upregulates growth factors such as TGF-β, which stimulate collagen biosynthesis and tissue regeneration. This makes it a valuable research tool in exploring mechanisms of dermal repair and anti-aging interventions. Moreover, its biomimetic design offers high biocompatibility, ensuring reliable integration into experimental cosmetic formulations for research on dermal remodeling, wrinkle reduction, and contour enhancement.Recent studies have demonstrated that Acetyl hexapeptide-38 can modulate adiponectin expression in adipose-derived cells, which may enhance lipid metabolism and promote subcutaneous volume recovery in aging skin. This molecular mechanism supports its use in cosmetic research targeting sagging, volume loss, and fine wrinkles — all hallmark indicators of skin aging. Researchers investigating advanced cosmeceutical formulations continue to integrate this peptide for its multifaceted biological actions and synergistic potential with other active compounds such as peptides, retinoids, and antioxidants.In laboratory settings, Acetyl hexapeptide-38 is typically evaluated for its impact on cell proliferation, matrix protein synthesis, and ECM remodeling in human dermal fibroblast cultures. Its structural specificity allows for high binding affinity to fibroblast receptors, thereby influencing downstream gene expression and enzymatic activity related to collagen production. This makes Acetyl hexapeptide-38 a promising biomimetic model for studying skin rejuvenation and regeneration processes.Beyond its primary dermal benefits, the peptide has also been explored for its potential in tissue repair research. Its ability to stimulate the synthesis of extracellular matrix components not only strengthens the dermal structure but also accelerates wound closure and improves post-surgical skin recovery in experimental models. As a result, Acetyl hexapeptide-38 continues to be used in studies focused on regenerative dermatology and soft-tissue engineering.Due to its favorable stability, water solubility, and compatibility with various formulation systems, Acetyl hexapeptide-38 is suitable for incorporation into serums, emulsions, and gel-based cosmetic prototypes designed for anti-aging and dermal restoration research. Its versatility and precision in modulating dermal structure make it one of the most investigated peptides for cosmetic science laboratories seeking innovative, high-purity peptide actives for skincare research applications.Product SpecificationsPropertyDescriptionProduct NameAcetyl hexapeptide-38CAS Number1400634-44-7Molecular FormulaC₃₄H₆₁N₉O₁₀Molecular Weight759.9 g/molPurity≥99%SynonymsDermican™, Collagen Stimulating PeptideAppearanceWhite to off-white lyophilized powderSolubilitySoluble in water and most polar solventsStorageStore at −20°C in a desiccated environmentStabilityStable for up to 3 years under recommended conditionsCategoryCosmetic Peptide / Anti-aging PeptideApplicationsAnti-aging research, dermal regeneration, collagen synthesis studiesResearch AreaSkin repair, tissue remodeling, anti-wrinkle mechanismSupplier TypeFactory peptide supplier, peptide wholesale ChinaIntended UseFor laboratory research use onlyMechanism of ActionAcetyl hexapeptide-38 functions by activating dermal fibroblasts, the key cells responsible for collagen and elastin synthesis within the extracellular matrix. Upon interaction, it upregulates the expression of COL1A1 and COL3A1 genes, thereby promoting collagen type I and III synthesis. These collagens form the structural backbone of healthy skin, ensuring firmness and elasticity.Additionally, the peptide enhances adiponectin signaling in subcutaneous tissue. Adiponectin plays an essential role in lipid metabolism and dermal matrix support. By stimulating adiponectin expression, Acetyl hexapeptide-38 increases the proliferation of adipocytes, leading to improved dermal thickness and subcutaneous structure. This dual fibroblast–adipocyte activity contributes to smoother, firmer, and more voluminous skin texture in laboratory studies.The mechanism also involves modulation of TGF-β (Transforming Growth Factor Beta) pathways. Acetyl hexapeptide-38 promotes ECM protein synthesis and downregulates matrix metalloproteinases (MMPs), which are enzymes responsible for collagen degradation. Consequently, the peptide helps maintain structural integrity and prevents age-related matrix breakdown in skin models.This peptide has also been shown to enhance integrin and laminin production, improving dermal adhesion and the dermal–epidermal junction. Through these complex molecular interactions, Acetyl hexapeptide-38 supports advanced research into anti-aging formulations designed to enhance structural skin resilience and volume restoration.Side EffectsNo direct toxicological effects have been reported for Acetyl hexapeptide-38 under laboratory research conditions. It is generally considered non-cytotoxic in standard in-vitro fibroblast assays. Researchers are advised to adhere to laboratory biosafety standards when handling the peptide. While the compound demonstrates strong dermal activity, it is not intended for clinical or therapeutic use.When used in formulation testing, the peptide maintains stability and bioactivity without causing cell lysis or inflammatory responses. Nonetheless, care should be taken to prevent contamination, degradation, or unvalidated combinations with other reagents. Laboratory studies should be conducted within established safety frameworks to ensure reliable data outcomes.KeywordsAcetyl hexapeptide-38, CAS 1400634-44-7, cosmetic peptide, collagen stimulation, skin firmness, dermal fibroblast activator, tissue repair peptide, high-purity cosmetic peptide, peptide wholesale China, factory peptide supplier, OEM peptide production, research peptide manufacturer, bulk peptide powder, collagen synthesis research, anti-aging peptide.Shipping GuaranteeAll shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.Trade AssuranceWe ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.Payment SupportWe provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.DisclaimerAll products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.